BMP-2 Information: BMP-2 Protein, BMP-2 Antibody and BMP-2 Gene

BMP-2 Gene family

BMP-2 Protein

BMP-2 protein function

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). {ECO:0000269|PubMed:24362451, ECO:0000269|PubMed:3201241}.

BMP-2 protein expression

Tissue specificity

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

BMP-2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

BMP-2 Antibody

There are 7 BMP-2 antibodies which are validated in multiple tissues with various applications, including ELISA(Det), ELISA, WB, IP, FCM, ICC/IF, ELISA(Cap). There are 1 BMP-2 antibody for ELISA(Det), 3 BMP-2 antibody for ELISA, 1 BMP-2 antibody for WB, 1 BMP-2 antibody for IP, 1 BMP-2 antibody for FCM, 2 BMP-2 antibody for ICC/IF, 1 BMP-2 antibody for ELISA(Cap). Among all these BMP-2 antibodies, there are 5 anti-BMP-2 mouse monoclonal antibodies , 1 anti-BMP-2 rabbit monoclonal antibodies , 1 anti-BMP-2 rabbit polyclonal antibodies . All the BMP-2 anbodies are produced in house and all are in stock. BMP-2 antibody customerized service is available.

BMP-2 Gene

BMP2 gene / cDNA is a protein-coding gene which located on 20p12.3. The BMP2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.226 organisms have orthologs with human gene BMP2.