BID Gene Sequence, Family, Fuction and Expression Information

BID cDNA / Gene Overview

BID gene / cDNA is a protein-coding gene which located on 22q11.21. The BID gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.189 organisms have orthologs with human gene BID.

BID cDNA / Gene Function

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

BID cDNA / Gene Sequence

LOCUS
LOCUS NM_197966 2535 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens BH3 interacting domain death agonist (BID), transcript variant 1, mRNA.
ACCESSION
NM_197966
VERSION
NM_197966.2

This sequence information is just for reference only.

BID Family & Reagents

BID Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
VIP
GNRH2
C3
BMP5
KNG1
CCL21
TGFB3
CD274
ICAM2
AGRP
Approved Symbol Reagent list
LIF
CCL1
XCL1
CCL27
CXCL3
FN1
INHBA
RSPO2
CCL20
CXCL1

BID Gene family reagents (BCL2 homology region 3 (BH3) only)

Approved Symbol Reagent list
BCL2L11
Approved Symbol Reagent list
BMF

BID cDNA / Gene Expression

Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 9.4) and 24 other tissues