beta-Catenin Information: beta-Catenin Protein, beta-Catenin Antibody and beta-Catenin Gene

beta-Catenin Gene family

beta-Catenin Protein

beta-Catenin protein function

Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). {ECO:0000250|UniProtKB:Q02248, ECO:0000269|PubMed:17524503, ECO:0000269|PubMed:18077326, ECO:0000269|PubMed:18086858, ECO:0000269|PubMed:18957423, ECO:0000269|PubMed:21262353, ECO:0000269|PubMed:22155184, ECO:0000269|PubMed:22647378, ECO:0000269|PubMed:22699938}.

beta-Catenin protein expression

Tissue specificity

Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level). Expressed in breast cancer tissues (at protein level) (PubMed:29367600).

beta-Catenin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

beta-Catenin Antibody

There are 3 beta-Catenin antibodies which are validated in multiple tissues with various applications, including WB, ELISA, IHC-P, FCM, ICC/IF. There are 1 beta-Catenin antibody for WB, 3 beta-Catenin antibody for ELISA, 2 beta-Catenin antibody for IHC-P, 1 beta-Catenin antibody for FCM, 1 beta-Catenin antibody for ICC/IF. Among all these beta-Catenin antibodies, there are 1 anti-beta-Catenin rabbit monoclonal antibodies , 2 anti-beta-Catenin rabbit polyclonal antibodies . All the beta-Catenin anbodies are produced in house and all are in stock. beta-Catenin antibody customerized service is available.

beta-Catenin Gene

CTNNB1 gene / cDNA is a protein-coding gene which located on 3p22.1. The CTNNB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.239 organisms have orthologs with human gene CTNNB1.