beta-Actin Protein Overview: Sequence, Structure, Function and Protein Interaction

beta-Actin Protein Overview

beta-Actin reagents

From studies of the amino acid sequence of cytoplasmic and muscle actins, Vandekerckhove and Weber (1978) concluded that mammalian cytoplasmic actins are the products of 2 different genes and differ by many amino acids from muscle actin. In a neoplastic cell line resulting from treatment of cultured human diploid fibroblasts with a chemical mutagen, Leavitt et al. (1982) observed a mutant form of beta actin. Toyama and Toyama (1984) isolated and characterized lines of KB cells resistant to cytochalasin B. They found that one resistant line had an alteration in beta-actin. Such cells bound less cytochalasin B than did parental KB cells. The authors suggested that the primary site of action of cytochalasin B on cell motility processes is beta-actin. Using chick beta-actin cDNA as probe, Gunning et al. (1983) cloned beta-actin and gamma-actin (ACTG1; 102560) from a fibroblast cDNA library. They noted that the N-terminal methionine is posttranslationally removed from the mature beta- and gamma-actin proteins.

beta-Actin protein family

Belongs to the actin family.

beta-Actin protein name

Recommended name
Actin, cytoplasmic 1
Aliases
β-actin
Alternative name
Beta-actin Actin, cytoplasmic 1, N-terminally processed

beta-Actin Protein Sequence

Species Human beta-Actin protein
Length 375
Mass (Da) 41737
Sequence Human beta-Actin protein sequence
Species Mouse beta-Actin protein
Length 375
Mass (Da) 41737
Sequence Mouse beta-Actin protein sequence
Species Rat beta-Actin protein
Length 375
Mass (Da) 41737
Sequence Rat beta-Actin protein sequence

beta-Actin Protein Molecular Weight & PI

Actin, cytoplasmic 1 (Beta-actin) [Contains: Actin, cytoplasmic 1, N-terminally processed]Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-375 Actin, cytoplasmic 1.

Molecular weight (Da)

41736.73

Theoretical pI

5.29

beta-Actin Protein Structure

Structure of UL18, a Peptide-Binding Viral MHC Mimic, Bound to a Host Inhibitory Receptor
Deposited
2008-05-08   Released:  2008-07-08
Deposition Author(s)
Yang, Z., Bjorkman, P.J.
Organism(s)
Homo sapiens, Human cytomegalovirus (strain AD169)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2100 Å
R-Value Free
0.259
R-Value Work
0.241
3D2U From PDB

beta-Actin Protein Interaction

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