BCRP/ABCG2 Protein Overview: Sequence, Structure, Function and Protein Interaction

BCRP/ABCG2 Protein Overview

BCRP/ABCG2 reagents

The ABCG2 gene encodes a membrane transporter belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes. ABCG2 was initially found to be a xenobiotic transporter that plays a role in the multidrug resistance phenotype of a specific human breast cancer (Doyle et al., 1998) and has since been shown to confer multidrug resistance in several cancer cells by actively exporting a wide variety of drugs across the plasma membrane. The ABCG2 protein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut (summary from Matsuo et al., 2009 and Saison et al., 2012). For general information on the ABC superfamily, see ABCA4 (601691).

BCRP/ABCG2 protein family

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

BCRP/ABCG2 protein name

Recommended name
ATP-binding cassette sub-family G member 2
Aliases
ABCP, BCRP, CD338, EST157481, MXR
Alternative name
Breast cancer resistance protein CDw338 Mitoxantrone resistance-associated protein Placenta-specific ATP-binding cassette transporter Urate exporter CD_antigen: CD338

BCRP/ABCG2 Protein Sequence

Species Human BCRP/ABCG2 protein
Length 655
Mass (Da) 72314
Sequence Human BCRP/ABCG2 protein sequence
Species Mouse BCRP/ABCG2 protein
Length 657
Mass (Da) 72978
Sequence Mouse BCRP/ABCG2 protein sequence
Species Rat BCRP/ABCG2 protein
Length 657
Mass (Da) 72961
Sequence Rat BCRP/ABCG2 protein sequence

BCRP/ABCG2 Protein Molecular Weight & PI

ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD338 antigen)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-655 ATP-binding cassette sub-family G member

Molecular weight (Da)

72314.18

Theoretical pI

8.91

BCRP/ABCG2 Protein Structure

Structure of inhibitor-bound ABCG2
Deposited
2017-10-26   Released:  2018-04-11
Deposition Author(s)
Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Altmann, K.H., Locher, K.P.
Organism(s)
Homo sapiens
Expression System
Mus musculus, Homo sapiens
Experimental Data Snapshot
Method
ELECTRON MICROSCOPY
6ETI From PDB

Human BCRP/ABCG2 protein Secondary structure

BCRP/ABCG2 Protein Interaction

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