B7-H4 Protein Overview: Sequence, Structure, Function and Protein Interaction

B7-H4 Protein Overview

B7H4 belongs to the B7 family (see CD80; 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; 186760) on T lymphocytes.

B7-H4 protein family

Belongs to the immunoglobulin superfamily. BTN/MOG family.

B7-H4 protein name

Recommended name
V-set domain-containing T-cell activation inhibitor 1
B7 family member, H4, B7 superfamily member 1, B7H4, B7-H4, B7S1, B7X, FLJ22418
Alternative name
B7 homolog 4 B7h.5 Immune costimulatory protein B7-H4 Protein B7S1 T-cell costimulatory molecule B7x

B7-H4 Gene family protein

B7-H4 Protein Sequence

Species Human B7-H4 protein
Length 282
Mass (Da) 30878
Sequence Human B7-H4 protein sequence
Species Mouse B7-H4 protein
Length 283
Mass (Da) 30875
Sequence Mouse B7-H4 protein sequence
Species Rat B7-H4 protein
Length 282
Mass (Da) 30664
Sequence Rat B7-H4 protein sequence

B7-H4 Protein Molecular Weight & PI

V-set domain-containing T-cell activation inhibitor 1 precursor (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 25-282 V-set domain-containing T-cell activation

Molecular weight (Da)


Theoretical pI


B7-H4 Protein Structure

Crystal structure of human B7-H4 IgV-like domain
2012-08-20   Released:  2012-09-12
Deposition Author(s)
Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
Homo sapiens
Expression System
Drosophila melanogaster
Experimental Data Snapshot
1.5900 Å
R-Value Free
R-Value Work

Human B7-H4 protein Secondary structure

B7-H4 Protein Interaction

Recombinant B7-H4 Protein Feature

B7-H4 Protein, Human, Recombinant (ECD, His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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