B7-H4 Protein Overview: Sequence, Structure, Function and Protein Interaction
B7-H4 Protein Overview
B7H4 belongs to the B7 family (see CD80; 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; 186760) on T lymphocytes.
B7-H4 protein family
Belongs to the immunoglobulin superfamily. BTN/MOG family.
B7-H4 protein name
Recommended name
V-set domain-containing T-cell activation inhibitor 1
Aliases
B7 family member, H4, B7 superfamily member 1, B7H4, B7-H4, B7S1, B7X, FLJ22418
Alternative name
B7 homolog 4
B7h.5
Immune costimulatory protein B7-H4
Protein B7S1
T-cell costimulatory molecule B7x
B7-H4 Gene family protein
V-set domain containing
| Approved symbol | Common name |
|---|---|
| MCAM | CD146/MCAM protein, recombinant |
| SLAMF6 | SLAMF6 protein, recombinant |
| NCR2 | NKp44/NCR2 protein, recombinant |
| JAML | JAML protein, recombinant |
| CD28 | CD28 protein, recombinant |
| CD7 | CD7 protein, recombinant |
| BTN3A1 | BTN3A1 protein, recombinant |
| PSG6 | PSG6 protein, recombinant |
| Vsir | VISTA protein, recombinant |
| CD79A | CD79A protein, recombinant |
| AXL | AXL protein, recombinant |
| PIGR | PIGR protein, recombinant |
| NCR3 | NKp30/NCR3 protein, recombinant |
| NECTIN1 | PVRL1/NECTIN1 protein, recombinant |
| CD33 | CD33 protein, recombinant |
| TREM2 | TREM-2 protein, recombinant |
| IGSF8 | IGSF8 protein, recombinant |
| FCAMR | FCAMR/CD351 protein, recombinant |
| NECTIN2 | Nectin-2 protein, recombinant |
| HAVCR1 | TIM-1/KIM-1 protein, recombinant |
Immunoglobulin like domain containing
| Approved symbol | Common name |
|---|---|
| ICAM5 | ICAM5 protein, recombinant |
| LY9 | CD229 protein, recombinant |
| IL12B | IL12B protein, recombinant |
| ICAM3 | CD50 protein, recombinant |
| CD200 | CD200 protein, recombinant |
| VSIG4 | VSIG4 protein, recombinant |
| THY1 | Thy1/CD90 protein, recombinant |
| CEACAM6 | CEACAM6 protein, recombinant |
| ALCAM | CD166/ALCAM protein, recombinant |
| IL6R | IL-6R protein, recombinant |
| NTRK1 | TrkA protein, recombinant |
| CEACAM8 | CD66b protein, recombinant |
| AGER | RAGE protein, recombinant |
| IL1RAPL1 | IL1RAPL1 protein, recombinant |
| IL18BP | IL18BP protein, recombinant |
| IL18R1 | IL18R1 protein, recombinant |
| CDON | CDO protein, recombinant |
| MUSK | MUSK protein, recombinant |
| HepaCAM2 | HEPACAM2 protein, recombinant |
| FCGR3A | CD16a protein, recombinant |
B7-H4 Protein Sequence
| Species | Human B7-H4 protein |
|---|---|
| Length | 282 |
| Mass (Da) | 30878 |
| Sequence | Human B7-H4 protein sequence |
| Species | Mouse B7-H4 protein |
|---|---|
| Length | 283 |
| Mass (Da) | 30875 |
| Sequence | Mouse B7-H4 protein sequence |
| Species | Rat B7-H4 protein |
|---|---|
| Length | 282 |
| Mass (Da) | 30664 |
| Sequence | Rat B7-H4 protein sequence |
B7-H4 Protein Molecular Weight & PI
V-set domain-containing T-cell activation inhibitor 1 precursor (B7 homolog 4) (B7-H4) (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x) Homo sapiens (Human).
The parameters have been computed for the following feature
FT CHAIN 25-282 V-set domain-containing T-cell activation
Molecular weight (Da)
28381.31
Theoretical pI
5.20
B7-H4 Protein Structure
Crystal structure of human B7-H4 IgV-like domain
Deposited
2012-08-20 Released: 2012-09-12
Deposition Author(s)
Vigdorovich, V., Ramagopal, U., Bhosle, R., Toro, R., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)
Organism(s)
Homo sapiens
Expression System
Drosophila melanogaster
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.5900 Å
R-Value Free
0.192
R-Value Work
0.174
4GOS From PDB
Human B7-H4 protein Secondary structure
B7-H4 Protein Interaction
Recombinant B7-H4 Protein Feature
B7-H4 Protein, Human, Recombinant (ECD, His Tag)
High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Bulk Order of Recombinant B7-H4 Protein
Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.
Custom Recombinant B7-H4 Protein Service
Custom Recombinant Protein Production Service Features
-
Over 10 years' experience for 6000+ recombinant proteins production.
-
One-stop service from gene synthesis and vector construction to protein expression and purification.
-
Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
-
Multiple purification systems (30+) to choose.
-
High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
-
Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.
Custom Recombinant Protein Production Service Advantages
- High-efficiency expression vectors
- High cell density culturing
- Proprietary medium formulation
- >6000 proteins expression and purification experience
- High-efficiency expression vectors
- High cell density culturing
Recombinant Protein Production Service Description
We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.
