alpha-2-macroglobulin Protein Overview: Sequence, Structure, Function and Protein Interaction

alpha-2-macroglobulin Protein Overview

alpha-2-macroglobulin reagents

A2M is a 718-kD homotetrameric glycoprotein of plasma and extracellular spaces that was first recognized as a broad spectrum protease inhibitor. A2M is activated by proteases with which it interacts, and this proteolytic activation causes a conformational change that traps the protease within the A2M homotetramer. In addition, A2M contains several independent domains that function as carriers of specific growth factors and/or binding sites for receptors. Activation of A2M by proteases alters the interaction of A2M with these ligands and induces cell signaling (summary by Mantuano et al., 2008).

alpha-2-macroglobulin protein family

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

alpha-2-macroglobulin protein name

Recommended name
Short name
CPAMD5, FWP007, S863-7
Alternative name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

alpha-2-macroglobulin Gene family protein

C3 and PZP like, alpha-2-macroglobulin domain containing

alpha-2-macroglobulin Protein Sequence

Species Human alpha-2-macroglobulin protein
Length 1474
Mass (Da) 163291
Sequence Human alpha-2-macroglobulin protein sequence
Species Mouse alpha-2-macroglobulin protein
Length 1495
Mass (Da) 165853
Sequence Mouse alpha-2-macroglobulin protein sequence
Species Rat alpha-2-macroglobulin protein
Length 1472
Mass (Da) 63785
Sequence Rat alpha-2-macroglobulin protein sequence

alpha-2-macroglobulin Protein Molecular Weight & PI

Alpha-2-macroglobulin precursor (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-1474 Alpha-2-macroglobulin.

Molecular weight (Da)


Theoretical pI


alpha-2-macroglobulin Protein Structure

Alpha-2 Macroglobulin
2011-12-17   Released:  2012-02-22
Deposition Author(s)
Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Homo sapiens
Experimental Data Snapshot
4.3000 Å
R-Value Free
R-Value Work

Human alpha-2-macroglobulin protein Secondary structure

alpha-2-macroglobulin Protein Interaction

Recombinant alpha-2-macroglobulin Protein Feature

alpha-2-macroglobulin Protein, Human, Recombinant (His Tag)

High Purity
> 85 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to trap trypsin. The trapped trypsin is no longer able to interact with protein substrates or inhibitors, but still able to cleave small peptide substrates or inhibitors. The IC50 value is <5 nM.

Recombinant alpha-2-macroglobulin protein citations

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin
N'Guessan, K;Grzywa, R;Seren, S;Gabant, G;Juliano, MA;Moniatte, M;van Dorsselaer, A;Bieth, J;Kellenberger, C;Gauthier, F;Wysocka, M;Lesner, A;Sienczyk, M;Cadene, M;Korkmaz, B;

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