Aggrecan/ACAN Protein Overview: Sequence, Structure, Function and Protein Interaction

Aggrecan/ACAN Protein Overview

Aggrecan/ACAN reagents

Aggrecan is a major component of cartilage extracellular matrix. The extent of glycosaminoglycan side chain substitution in aggrecan and resulting fixed charge density attracts counter-ions and water, resulting in swelling pressure that is crucial for the biomechanical properties of cartilage (Day et al., 2004).

Aggrecan/ACAN protein family

Belongs to the aggrecan/versican proteoglycan family.

Aggrecan/ACAN protein name

Recommended name
Aggrecan core protein
aggrecan proteoglycan, CSPGCP
Alternative name
Cartilage-specific proteoglycan core protein CSPCP Chondroitin sulfate proteoglycan core protein 1 Chondroitin sulfate proteoglycan 1 Aggrecan core protein 2 Aggrecan core protein 2

Aggrecan/ACAN Gene family protein

Aggrecan/ACAN Protein Sequence

Species Human Aggrecan/ACAN protein
Length 2530
Mass (Da) 261329
Sequence Human Aggrecan/ACAN protein sequence
Species Mouse Aggrecan/ACAN protein
Length 2132
Mass (Da) 221941
Sequence Mouse Aggrecan/ACAN protein sequence
Species Rat Aggrecan/ACAN protein
Length 2124
Mass (Da) 221118
Sequence Rat Aggrecan/ACAN protein sequence

Aggrecan/ACAN Protein Molecular Weight & PI

Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Contains: Aggrecan core protein 2]Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 17-2530 Aggrecan core protein.

Molecular weight (Da)


Theoretical pI


Aggrecan/ACAN Protein Structure

Immune Receptor
2013-08-22   Released:  2013-12-04
Deposition Author(s)
Scally, S.W., Rossjohn, J.
Homo sapiens
Expression System
Homo sapiens
Experimental Data Snapshot
1.9500 Å
R-Value Free
R-Value Work
4MD4 From PDB

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