Aggrecan/ACAN Protein Overview: Sequence, Structure, Function and Protein Interaction

Aggrecan/ACAN Protein Overview

Aggrecan/ACAN reagents

Aggrecan is a major component of cartilage extracellular matrix. The extent of glycosaminoglycan side chain substitution in aggrecan and resulting fixed charge density attracts counter-ions and water, resulting in swelling pressure that is crucial for the biomechanical properties of cartilage (Day et al., 2004).

Aggrecan/ACAN protein family

Belongs to the aggrecan/versican proteoglycan family.

Aggrecan/ACAN protein name

Recommended name
Aggrecan core protein
Aliases
aggrecan proteoglycan, CSPGCP
Alternative name
Cartilage-specific proteoglycan core protein CSPCP Chondroitin sulfate proteoglycan core protein 1 Chondroitin sulfate proteoglycan 1 Aggrecan core protein 2 Aggrecan core protein 2

Aggrecan/ACAN Gene family protein

Aggrecan/ACAN Protein Sequence

Species Human Aggrecan/ACAN protein
Length 2530
Mass (Da) 261329
Sequence Human Aggrecan/ACAN protein sequence
Species Mouse Aggrecan/ACAN protein
Length 2132
Mass (Da) 221941
Sequence Mouse Aggrecan/ACAN protein sequence
Species Rat Aggrecan/ACAN protein
Length 2124
Mass (Da) 221118
Sequence Rat Aggrecan/ACAN protein sequence

Aggrecan/ACAN Protein Molecular Weight & PI

Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Contains: Aggrecan core protein 2]Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 17-2530 Aggrecan core protein.

Molecular weight (Da)

259482.22

Theoretical pI

4.05

Aggrecan/ACAN Protein Structure

Immune Receptor
Deposited
2013-08-22   Released:  2013-12-04
Deposition Author(s)
Scally, S.W., Rossjohn, J.
Organism(s)
Homo sapiens
Expression System
Homo sapiens
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9500 Å
R-Value Free
0.209
R-Value Work
0.165
4MD4 From PDB

Bulk Order of Recombinant Aggrecan/ACAN Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.