ACOX3 Protein Overview: Sequence, Structure, Function and Protein Interaction

ACOX3 Protein Overview

ACOX3 reagents

In rat, 2-methyl branched fatty acids and the bile acid intermediates di- and tri-hydroxycoprostanic acids are desaturated in the peroxisomes by pristanoyl-CoA oxidase and trihydroxycoprostanoyl-CoA oxidase, respectively. In humans these compounds are oxidized by a single enzyme, branched-chain acyl-CoA oxidase (ACOX2; 601641), which is homologous to rat trihydroxycoprostanoyl-CoA oxidase. Vanhooren et al. (1997) stated that Western and Northern blot analyses had previously shown that pristanoyl-CoA oxidase is not found in human tissues. However, by searching an EST database, they identified several human partial cDNAs with homology to rat pristanoyl-CoA oxidase. They screened a liver library with a rat pristanoyl-CoA oxidase cDNA and recovered a cDNA corresponding to the entire coding region of the human protein. The predicted 700-amino acid human pristanoyl-CoA oxidase contains a C-terminal SKL (ser-lys-leu) peroxisomal targeting sequence. The human and rat enzymes share 75% sequence identity.

ACOX3 protein family

Belongs to the acyl-CoA oxidase family.

ACOX3 protein name

Recommended name
Peroxisomal acyl-coenzyme A oxidase 3

ACOX3 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 2-700 Peroxisomal acyl-coenzyme A oxidase 3.

Molecular weight (Da)

77497.89

Theoretical pI

6.88

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