Aconitase 1/ACO1 Protein Overview: Sequence, Structure, Function and Protein Interaction

Aconitase 1/ACO1 Protein Overview

Aconitase 1/ACO1 reagents

Soluble aconitase is a bifunctional protein with mutually exclusive functions as an iron responsive element (IRE)-binding protein involved in the control of iron metabolism or as the cytoplasmic isoform of aconitase. Aconitases are iron-sulfur proteins that require a 4Fe-4S cluster for their enzymatic activity, in which they catalyze conversion of citrate to isocitrate (EC (Eisenstein, 2000).

Aconitase 1/ACO1 protein family

Belongs to the aconitase/IPM isomerase family.

Aconitase 1/ACO1 protein name

Recommended name
Cytoplasmic aconitate hydratase
Short name
aconitate hydratase, cytoplasmic, cytosplasmic aconitase, IREBP, IRP1, soluble aconitase
Alternative name
Citrate hydro-lyase Ferritin repressor protein Iron regulatory protein 1 IRP1 Iron-responsive element-binding protein 1 IRE-BP 1

Aconitase 1/ACO1 Protein Sequence

Species Human Aconitase 1/ACO1 protein
Length 889
Mass (Da) 98399
Sequence Human Aconitase 1/ACO1 protein sequence
Species Mouse Aconitase 1/ACO1 protein
Length 889
Mass (Da) 98126
Sequence Mouse Aconitase 1/ACO1 protein sequence
Species Rat Aconitase 1/ACO1 protein
Length 889
Mass (Da) 98128
Sequence Rat Aconitase 1/ACO1 protein sequence

Aconitase 1/ACO1 Protein Molecular Weight & PI

Cytoplasmic aconitate hydratase (EC (Aconitase) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-889 Cytoplasmic aconitate hydratase.

Molecular weight (Da)


Theoretical pI


Aconitase 1/ACO1 Protein Structure

Structure of a monoclinic crystal form of human cytosolic aconitase (IRP1)
2005-09-22   Released:  2006-01-10
Deposition Author(s)
Dupuy, J., Fontecilla-Camps, J.C., Volbeda, A.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
1.8500 Å
R-Value Free
R-Value Work
2B3Y From PDB

Human Aconitase 1/ACO1 protein Secondary structure

Aconitase 1/ACO1 Protein Interaction

Recombinant Aconitase 1/ACO1 Protein Feature

Aconitase 1/ACO1 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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