Acid Phosphatase/ACP1 Protein Overview: Sequence, Structure, Function and Protein Interaction

Acid Phosphatase/ACP1 Protein Overview

Acid Phosphatase/ACP1 reagents

Wo et al. (1992) cloned genes encoding 2 low molecular weight phosphotyrosyl protein phosphatases from a human placenta cDNA library. They were found to have identical nucleotide sequences, with the exception of a 108-bp segment in the middle of the open reading frame. From further studies they concluded that the 2 represent the fast and slow electrophoretic forms of red cell acid phosphatase and that this enzyme is not unique to the red cell but instead is expressed in all human tissues.

Acid Phosphatase/ACP1 protein family

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Acid Phosphatase/ACP1 protein name

Recommended name
Low molecular weight phosphotyrosine protein phosphatase
Short name
acid phosphatase of erythrocyte, HAAP, LMWPTP, LMW-PTP, low molecular weight phosphotyrosine protein phosphatase, red cell acid phosphatase
Alternative name
Adipocyte acid phosphatase Low molecular weight cytosolic acid phosphatase Red cell acid phosphatase 1

Acid Phosphatase/ACP1 Gene family protein

Acid Phosphatase/ACP1 Protein Sequence

Species Human Acid Phosphatase/ACP1 protein
Length 158
Mass (Da) 18042
Sequence Human Acid Phosphatase/ACP1 protein sequence
Species Mouse Acid Phosphatase/ACP1 protein
Length 158
Mass (Da) 18192
Sequence Mouse Acid Phosphatase/ACP1 protein sequence
Species Rat Acid Phosphatase/ACP1 protein
Length 158
Mass (Da) 18152
Sequence Rat Acid Phosphatase/ACP1 protein sequence

Acid Phosphatase/ACP1 Protein Molecular Weight & PI

Low molecular weight phosphotyrosine protein phosphatase (EC (LMW-PTP) (LMW-PTPase) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC (Red cell acid phosphatase 1)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-158 Low molecular weight phosphotyrosine

Molecular weight (Da)


Theoretical pI


Acid Phosphatase/ACP1 Protein Structure

Crystal Structure of Human B-form Low Molecular Weight Phosphotyrosyl Phosphatase at 1.6 Angstrom Resolution
2004-11-02   Released:  2005-11-01
Deposition Author(s)
Stauffacher, C.V., Zabell, A.P.R.
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
1.6300 Å
R-Value Free
R-Value Work

Human Acid Phosphatase/ACP1 protein Secondary structure

Acid Phosphatase/ACP1 Protein Interaction

Recombinant Acid Phosphatase/ACP1 Protein Feature

Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST Tag)

High Purity
> 88 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >65,000 pmol/min/μg.

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