Acetylcholinesterase Protein Overview: Sequence, Structure, Function and Protein Interaction

Acetylcholinesterase Protein Overview

Acetylcholinesterase reagents

Acetylcholinesterase (ACHE; EC controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly (summary by Xie et al., 2010).

Acetylcholinesterase protein family

Belongs to the type-B carboxylesterase/lipase family.

Acetylcholinesterase protein name

Recommended name
Short name
Yt blood group

Acetylcholinesterase Protein Sequence

Species Human Acetylcholinesterase protein
Length 614
Mass (Da) 67796
Sequence Human Acetylcholinesterase protein sequence
Species Mouse Acetylcholinesterase protein
Length 614
Mass (Da) 68169
Sequence Mouse Acetylcholinesterase protein sequence
Species Rat Acetylcholinesterase protein
Length 614
Mass (Da) 68196
Sequence Rat Acetylcholinesterase protein sequence

Acetylcholinesterase Protein Molecular Weight & PI

Acetylcholinesterase precursor (EC (AChE)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 32-614 Acetylcholinesterase.

Molecular weight (Da)


Theoretical pI


Acetylcholinesterase Protein Structure

Structure of the tetramerization domain of acetylcholinesterase: four-fold interaction of a WWW motif with a left-handed polyproline helix
2004-05-20   Released:  2005-01-10
Deposition Author(s)
Dvir, H., Harel, M., Bon, S., Liu, W.-Q., Vidal, M., Garbay, C., Sussman, J.L., Massoulie, J., Silman, I.
Homo sapiens
Experimental Data Snapshot
2.3500 Å
R-Value Free
R-Value Work

Human Acetylcholinesterase protein Secondary structure

Acetylcholinesterase Protein Interaction

Recombinant Acetylcholinesterase Protein Feature

Acetylcholinesterase Protein, Mouse, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to cleave Acetylthiocholine. The specific activity is > 250 nmols/min/μg.

Recombinant Acetylcholinesterase protein citations

Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1
Sperling, LE;Klaczinski, J;Schütz, C;Rudolph, L;Layer, PG;

Bulk Order of Recombinant Acetylcholinesterase Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant Acetylcholinesterase Protein Service

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.