ACADM/MCAD Protein Overview: Sequence, Structure, Function and Protein Interaction

ACADM/MCAD Protein Overview

ACADM/MCAD reagents

Matsubara et al. (1986) stated that 5 acyl-CoA dehydrogenases had been reported: short-chain (606885), medium-chain (EC 1.3.99.3), and long-chain (609576) acyl-CoA dehydrogenases; isovaleryl-CoA dehydrogenase (243500); and 2-methyl branched-chain acyl-CoA dehydrogenase. The first 3 catalyze the initial reaction in the beta-oxidation of fatty acids, while the last 2 catalyze the dehydrogenation of branched short-chain acyl-CoAs in the metabolism of the branched-chain amino acids. All 5 may have evolved from a common ancestral gene.

ACADM/MCAD protein family

Belongs to the acyl-CoA dehydrogenase family.

ACADM/MCAD protein name

Recommended name
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Aliases
ACAD1, MCAD, MCADH, medium-chain acyl-CoA dehydrogenase

ACADM/MCAD Gene family protein

Acyl-CoA dehydrogenase family
Approved symbol Common name
GCDH GCDH protein, recombinant
IVD IVD protein, recombinant

ACADM/MCAD Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 26-421 Medium-chain specific acyl-CoA

Molecular weight (Da)

43642.89

Theoretical pI

7.02

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