ACAD8 Protein Overview: Sequence, Structure, Function and Protein Interaction

ACAD8 Protein Overview

ACAD8 reagents

By constructing a transcript map of a region on chromosome 11q25, together with searching the Unigene database, Telford et al. (1999) identified the ACAD8 gene. They isolated an ACAD8 cDNA containing a full-length coding sequence using RT-PCR on RNA from human adult brain and skin fibroblast. The predicted 415-amino acid ACAD8 protein contains many of the residues conserved in most other ACADs, including an active site glutamic acid residue and residues important for tetramer formation. Amino acid sequence identity between ACAD8 and other known ACADs range from 28% with GCDH to 38% with short-chain ACAD (ACADS; 606885). Northern blot analysis detected an approximately 2.1-kb ACAD8 transcript in all tissues examined, namely heart, lung, brain, skeletal muscle, pancreas, placenta, liver, and kidney, although it was weakly expressed in the last 2 tissues. RT-PCR showed ACAD8 expression in human cochlea and the myeloid cell line KG-1.

ACAD8 protein family

Belongs to the acyl-CoA dehydrogenase family.

ACAD8 protein name

Recommended name
Isobutyryl-CoA dehydrogenase, mitochondrial

ACAD8 Gene family protein

Acyl-CoA dehydrogenase family
Approved symbol Common name
GCDH GCDH protein, recombinant
IVD IVD protein, recombinant

ACAD8 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 23-415 Isobutyryl-CoA dehydrogenase,

Molecular weight (Da)

42681.86

Theoretical pI

6.77

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