ACAD11 Protein Overview: Sequence, Structure, Function and Protein Interaction

ACAD11 Protein Overview

ACAD11 reagents

By database analysis and PCR of human liver, He et al. (2011) cloned ACAD11. They also identified several ACAD11 spice variants that differ predominantly in their 3-prime and 5-prime ends. The deduced full-length ACAD11 protein contains an N-terminal aminoglycoside phosphotransferase domain, followed by a mitochondria localization signal and ACAD N-terminal, middle, and C-terminal domains. It also has a glycosylation site and a C-terminal peroxisome-targeting signal. The ACAD domain contains a catalytic aspartate rather than the catalytic glutamate found in most other ACADs. Real-time RT-PCR detected variable ACAD11 expression in all tissues examined, with highest expression in adult brain, followed by heart, liver, spinal cord, and kidney. Western blot analysis of fractionated human cerebellum and kidney revealed that ACAD11 associated with mitochondrial membranes, but not mitochondrial matrix. Immunohistochemical analysis showed that ACAD11 colocalized with a mitochondrial marker in human neuroblastoma cells. However, in human skin fibroblasts, ACAD11 predominantly localized to punctate cytoplasmic vesicles and nuclei. In human cerebellum, ACAD11 was predominantly expressed in oligodendrocyte-like cells of the white matter.

ACAD11 protein family

Belongs to the acyl-CoA dehydrogenase family.

ACAD11 protein name

Recommended name
Acyl-CoA dehydrogenase family member 11
Aliases
FLJ12592

ACAD11 Gene family protein

Acyl-CoA dehydrogenase family
Approved symbol Common name
GCDH GCDH protein, recombinant
IVD IVD protein, recombinant

ACAD11 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-780 Acyl-CoA dehydrogenase family member 11.

Molecular weight (Da)

87283.44

Theoretical pI

8.35

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