ACAA1 Protein Overview: Sequence, Structure, Function and Protein Interaction

ACAA1 Protein Overview

ACAA1 reagents

Bout et al. (1991) characterized the human peroxisomal 3-oxoacyl-CoA thiolase, or ACAA (acetyl-coenzyme A acyltransferase), gene. They reported that there are 2 peroxisomal thiolase genes in rat, but only 1 in human. Sequence analysis revealed that the deduced 424-amino acid human protein shares 87% sequence identity with rat peroxisomal thiolase. See also sterol carrier protein-2 (SCP2; 184755), the second peroxisomal thiolase to be identified.

ACAA1 protein family

Belongs to the thiolase family.

ACAA1 protein name

Recommended name
3-ketoacyl-CoA thiolase, peroxisomal
Aliases
peroxisomal 3-oxoacyl-Coenzyme A thiolase
Alternative name
Acetyl-CoA acyltransferase Beta-ketothiolase Peroxisomal 3-oxoacyl-CoA thiolase

ACAA1 Protein Sequence

Species Human ACAA1 protein
Length 424
Mass (Da) 44292
Sequence Human ACAA1 protein sequence
Species
Length
Mass (Da)
Sequence
Species
Length
Mass (Da)
Sequence

ACAA1 Protein Molecular Weight & PI

3-ketoacyl-CoA thiolase, peroxisomal precursor (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Peroxisomal 3-oxoacyl-CoA thiolase)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 27-424 3-ketoacyl-CoA thiolase, peroxisomal.

Molecular weight (Da)

41490.68

Theoretical pI

8.68

ACAA1 Protein Structure

Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1)
Deposited
2006-09-28   Released:  2006-10-10
Deposition Author(s)
Papagrigoriou, E., Johansson, C., Smee, C., Kavanagh, K., Pike, A.C.W., Sundstrom, M., Weigelt, J., Edwards, A., Arrowsmith, C.H., Gileadi, O., Gorrec, F., Umeano, C., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.5500 Å
R-Value Free
0.223
R-Value Work
0.179
2IIK From PDB

Human ACAA1 protein Secondary structure

ACAA1 Protein Interaction

Recombinant ACAA1 Protein Feature

ACAA1 Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

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