ABT1 Protein Overview: Sequence, Structure, Function and Protein Interaction

ABT1 Protein Overview

ABT1 reagents

Fukita et al. (1993) cloned the human homolog of the murine Smubp2 gene. The deduced 993-amino acid belongs to the putative helicase superfamily and shows 76.5% homology to the murine protein. A domain essential for DNA binding at residues 638 to 786 was identified. Expression of SMUBP2 mRNA was ubiquitous and augmented in spleen cells stimulated with lipopolysaccharide and interleukin-4 (IL4; 147780). Sebastiani et al. (1995) noted that mouse Catf1 is a 989-amino acid protein that represents a novel type of mammalian transcription factor. Catf1 contains ATP-binding and helicase-like motifs and a DNA-binding domain with no homology to any known DNA-binding motif. Catf1 mRNA expression was highly controlled in a tissue-specific fashion in the newborn rat, with highest expression in heart. In adult mouse tissues, Sebastiani et al. (1995) detected the highest level of Catf1 mRNA in heart, with low levels in other tissues. Sebastiani et al. (1995) noted a high degree of amino acid sequence conservation between the rat Catf1 and the human and mouse SMUBP2 proteins and suggested that these are homologs. Cottenie et al. (2014) found expression of the IGHMBP2 gene in the developing and adult human brain, with highest expression in the cerebellum. Expression in other body tissues was ubiquitous, with moderate expression in fibroblasts and lymphoblastic cell lines.

ABT1 protein family

Belongs to the ESF2/ABP1 family.

ABT1 protein name

Recommended name
Activator of basal transcription 1
Aliases
Esf2

ABT1 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-272 Activator of basal transcription 1.

Molecular weight (Da)

31078.95

Theoretical pI

9.87

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