ABO Protein Overview: Sequence, Structure, Function and Protein Interaction

ABO Protein Overview

ABO reagents

TRANSFERASE B, ALPHA 1-3-GALACTOSYLTRANSFERASE, INCLUDED

ABO protein family

Belongs to the glycosyltransferase 6 family.

ABO protein name

Recommended name
Histo-blood group ABO system transferase
Aliases
A3GALNT, A3GALT1
Alternative name
Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase A transferase Histo-blood group B transferase B transferase NAGAT Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form

ABO Protein Sequence

Species Human ABO protein
Length 354
Mass (Da) 40934
Sequence Human ABO protein sequence
Species Mouse ABO protein
Length 332
Mass (Da) 38777
Sequence Mouse ABO protein sequence
Species Rat ABO protein
Length 348
Mass (Da) 40375
Sequence Rat ABO protein sequence

ABO Protein Molecular Weight & PI

Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Contains: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-354 Histo-blood group ABO system transferase.

Molecular weight (Da)

40933.82

Theoretical pI

9.14

ABO Protein Structure

Crystal structure of unliganded GTB P156L
Deposited
2011-01-31   Released:  2012-02-15
Deposition Author(s)
Weadge, J., Palcic, M.M., Henriksen, A.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0600 Å
R-Value Free
0.245
R-Value Work
0.216
2Y7A From PDB

Human ABO protein Secondary structure

Recombinant ABO Protein Feature

ABO Protein, Human, Recombinant (hFc Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

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