ABI3 Protein Overview: Sequence, Structure, Function and Protein Interaction

ABI3 Protein Overview

ABI3 reagents

By screening a hepatocellular cDNA library using PCR with degenerate primers corresponding to p53 (191170)/p73 (601990) exon domains, followed by probing a placenta cDNA library, Miyazaki et al. (2000) obtained a cDNA encoding an SH3-containing protein they designated NESH (new molecule including SH3). SH3 domains contain about 50 amino acids that bind to proline-rich sequences and often play a role in cell growth signaling. Sequence analysis predicted that the 366-amino acid NESH protein, which is most homologous to SSH3BP1 (603050), has a central serine-rich region followed by a proline-rich region and a C-terminal SH3 domain. RT-PCR analysis detected variable expression of NESH in all tissues tested. Miyazaki et al. (2000) suggested that the similarity of NESH to SSH3BP1, an EPS8 (600206)-binding protein, indicates that its SH3 domain may interact with other proteins in signal transduction.

ABI3 protein family

Belongs to the ABI family.

ABI3 protein name

Recommended name
ABI gene family member 3

ABI3 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-366 ABI gene family member 3.

Molecular weight (Da)


Theoretical pI


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