ABCE1 Protein Overview: Sequence, Structure, Function and Protein Interaction

ABCE1 Protein Overview

ABCE1 reagents

The 2-5A/RNase L system is a main pathway for viral interferon (147660) action and may play a general role in RNA metabolism. In the pathway, IFN stimulation activates 2-5A synthetases which convert ATP into a set of unusual oligomers known as 2-5A; these oligomers in turn activate RNase L (RNase 4; 180435), which leads to inhibition of protein synthesis by cleaving mRNAs at the 3-prime side of UpNp sequences (summary by Bisbal et al., 1995). Bisbal et al. (1995) described the RNase L inhibitor, a potentially important mediator of the 2-5A/RNase L pathway. RNase L inhibitor blocks the activity of ribonuclease L. The authors cloned the human RNase L inhibitor (symbolized RLI by them) from a Daudi cell expression cDNA library using a radiolabeled 2-5ApCp oligomer. The full-length RLI cDNA encodes a predicted 599-amino acid protein which contains 2 repeated ATP/GTP-binding motifs and an internal repeat of 128 amino acids with 53% sequence identity to each other. Northern blots showed 3.5- and 2.8-kb transcripts in HeLa and Daudi cells which differ in their 3-prime untranslated regions. When the mRNA was expressed in reticulocyte extracts Bisbal et al. (1995) showed that both 2-5A binding and nuclease activities of RNase L were abrogated. Furthermore, they found that the inhibition occurred through association of the inhibitor with RNase L and both proteins were coprecipitated with a nuclease-specific monoclonal antibody. Aubry et al. (1996) also cloned the RNS4I gene and found both a 3.8-kb and a 2.4-kb transcript expressed differentially in all tissues examined. Highest expression of the 2.4-kb transcript was found in the testis, while the 3.8-kb transcript was most abundant in ovaries, testis, spleen, and pancreas.

ABCE1 protein family

Belongs to the ABC transporter superfamily. ABCE family.

ABCE1 protein name

Recommended name
ATP-binding cassette sub-family E member 1
Aliases
OABP, RLI, RLI1, RNase L inhibitor 1

ABCE1 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-599 ATP-binding cassette sub-family E member

Molecular weight (Da)

67314.34

Theoretical pI

8.63

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