ABCD1 Protein Overview: Sequence, Structure, Function and Protein Interaction

ABCD1 Protein Overview

ABCD1 reagents

ABCD1 (ALDP) maps to Xq28 and is mutated in the X-linked disorder adrenoleukodystrophy (ALD; 300100). ABCD1 is a member of the ATP-binding cassette (ABC) transporter superfamily. The superfamily contains membrane proteins that translocate a wide variety of substrates across extra- and intracellular membranes, including metabolic products, lipids and sterols, and drugs. Overexpression of certain ABC transporters occurs in cancer cell lines and tumors that are multidrug resistant such as ABCB1/MDR1 (171050), ABCC1/MRP1 (158343), and ABCG2 (603756). The family also includes ABCC7/CFTR (602421), the gene mutated in the autosomal recessive condition cystic fibrosis (Dean et al., 2001).

ABCD1 protein family

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

ABCD1 protein name

Recommended name
ATP-binding cassette sub-family D member 1
Aliases
adrenoleukodystrophy, ALDP, AMN
Alternative name
Adrenoleukodystrophy protein

ABCD1 Protein Sequence

Species Human ABCD1 protein
Length 745
Mass (Da) 82937
Sequence Human ABCD1 protein sequence
Species Mouse ABCD1 protein
Length 736
Mass (Da) 81859
Sequence Mouse ABCD1 protein sequence
Species Rat ABCD1 protein
Length 737
Mass (Da) 81938
Sequence Rat ABCD1 protein sequence

ABCD1 Protein Molecular Weight & PI

ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy protein) (ALDP)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-745 ATP-binding cassette sub-family D member

Molecular weight (Da)

82936.93

Theoretical pI

9.09

ABCD1 Protein Interaction

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