Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
ABCC1 protein expression
Tissue specificity
Lung, testis and peripheral blood mononuclear cells.
ABCC1 cDNA / gene is a gene with protein product which located on 16p13.11. The ABCC1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, A.thaliana, and rice. 171 organisms have orthologs with human gene ABCC1.
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