Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
ABCB11 protein expression
Tissue specificity
Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
ABCB11 cDNA / gene is a gene with protein product which located on 2q31.1. The ABCB11 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. 222 organisms have orthologs with human gene ABCB11.
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