ABCA7 Information: ABCA7 Protein, ABCA7 Antibody and ABCA7 Gene

ABCA7 Gene family

ABCA7 Protein

ABCA7 protein function

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

ABCA7 protein expression

Tissue specificity

Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow.

Induction

Up-regulated in macrophages upon cholesterol uptake and inversely regulated upon cholesterol deloading from the cells (at protein level). Up-regulated in keratinocytes during terminal differentiation.

ABCA7 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    2,146.00
  • Mass (Da)
    234.00

ABCA7 Gene

ABCA7 cDNA / gene is a gene with protein product which located on 19p13.3. The ABCA7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. 149 organisms have orthologs with human gene ABCA7.