AATF Information: AATF Protein, AATF Antibody and AATF Gene

AATF Protein

AATF protein function

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

AATF protein expression

Tissue specificity

Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.

AATF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    560.00
  • Mass (Da)
    63.00

AATF Gene

AATF cDNA / gene is a gene with protein product which located on 17q12. The AATF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, rice, and frog. 235 organisms have orthologs with human gene AATF.