AASDHPPT Protein Overview: Sequence, Structure, Function and Protein Interaction

AASDHPPT Protein Overview

AASDHPPT reagents

In mammals, L-lysine is first catabolized to alpha-aminoadipate semialdehyde by the bifunctional enzyme alpha-aminoadipate semialdehyde synthase (AASS; 605113), followed by a conversion to alpha-aminoadipate (AAA) by alpha-aminoadipate semialdehyde dehydrogenase (AASDH). In S. cerevisiae, which synthesize rather than degrade lysine, the latter activity requires 2 distinct genes. LYS2 encodes the alpha-aminoadipate reductase activity, while LYS5 encodes a phosphopantetheinyl transferase activity that is required to activate LYS2 protein.

AASDHPPT protein family

Belongs to the P-Pant transferase superfamily. AcpS family.

AASDHPPT protein name

Recommended name
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Aliases
AASD-PPT, ACPS, CGI-80, holo ACP synthase, holo-[acyl-carrier-protein] synthase, LYS5

AASDHPPT Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-309 L-aminoadipate-semialdehyde

Molecular weight (Da)

35775.95

Theoretical pI

6.35

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