AAK1 Information: AAK1 Protein, AAK1 Antibody and AAK1 Gene

AAK1 Protein

AAK1 protein function

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

AAK1 protein expression

Tissue specificity

Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain.

AAK1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    961.00
  • Mass (Da)
    103.00

AAK1 Gene

AAK1 cDNA / gene is a gene with protein product which located on 2p13.3. The AAK1 gene is conserved in chimpanzee, dog, mouse, rat, and chicken. 205 organisms have orthologs with human gene AAK1.