A2ML1 Information: A2ML1 Protein, A2ML1 Antibody and A2ML1 Gene

A2ML1 Gene family

A2ML1 Protein

A2ML1 protein function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

A2ML1 protein expression

Tissue specificity

In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.


Up-regulated during keratinocyte differentiation.

A2ML1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

A2ML1 Gene

A2ML1 cDNA / gene is a gene with protein product which located on 12p13.31. The A2ML1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, chicken, and frog. 117 organisms have orthologs with human gene A2ML1.