Activin Receptor

Like other TGF-beta superfamily receptors members, activin receptor, transduces signals through type I and II receptor serine/threonine kinases. The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor (ALK4 and/or ALK7), which then phosphorylates the Smad 2 and Smad 3 intracellular signaling proteins.

activin receptors

There are mainly two types of activin receptors. Type I activin receptors include ACVR1B and ACVR1C. Type II activin receptors include ACVR2A, ACVR2B and BMPR2.

Activin receptor and other TGF-beta superfamily receptors members signaling through Smad 2 and 3 were found to maintain human embryonic stem cell (hESC) pluripotency and self-renewal and that blocking activin signaling resulted in hESC differentiation.

Activin Receptor Products List

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