Drug targets for Cancer: OX40L

Drug Targets for Cancer: OX40L and Cancer

OX40L (known as TNFSF4, CD252), the cognate ligand of OX40, is a member of the tumor necrosis factor superfamily. The OX40L gene is located on human chromosome 1 and encodes a type II glycoprotein which expressed not only on professional antigen-presenting cells (APCs), but also on CD4+T cells, CD8+T cells, vascular endothelial cells, mast cells and activated NK cells. The interaction between OX40 and OX40L provides a costimulatory signal that strongly regulates the proliferation and survival of T lymphocytes, modulates NKT cell and NK cell function, and contributes to the differentiation and activity of regulatory T cells. Antitumor immunity provides a protective barrier to cancer formation and progression. Accumulating evidence indicates that inflammatory response plays a decisive role at different stages of cancer development and contributes to the initiation and progression of cancer. Moreover, avoiding immune destruction was considered as an emerging hallmark of cancer.

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Other vital drug targets for cancer like OX40L:

Drug Targets for Cancer: OX40L Related Reference

Weiguang Y, Dalin L, Lidan X, et al. Association of OX40L Polymorphisms with Sporadic Breast Cancer in Northeast Chinese Han Population. Lafrenie R, ed. PLoS ONE. 2012;7(8):e41277.

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