Matrix metalloproteinase-7 (MMP-7, matrilysin-1) has been implicated in tumour invasion–metastasis and in tumour initiation or growth in gastrointestinal and other cancers. Furthermore, positivity for MMP-7, rather than other MMP molecules, significantly correlates with the extent of tumour invasion, lymph node and distant metastasis, and advanced tumour stage in pancreatic carcinoma.MMP-7 is involved in cell dissociation and the subsequent invasion of pancreatic cancer cells. It induces the disruption of TJ structures and forms a positive feedback loop with activation of the EGFR mediated MEK–ERK signalling pathway.
Tan X, Egami H, Abe M, Nozawa F, Hirota M, Ogawa M. Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK–ERK signal transduction pathway. Journal of Clinical Pathology. 2005;58(12):1242-1248.