MMP-10 is a relatively understudied MMP in cancer biology. MMP-10 (also known as stromelysin 2) is generally limited to epithelial cells and can target pro-MMP-1, -7, -8, -9, -13, collagen type III, IV, V, gelatin, elastin, fibronectin, proteoglycans and laminin, activities that have been shown to promote tumor cell invasion. It has been demonstrated that MMP-10 expression is increased in several human tumors of epithelial origin, including gastric cancer, bladder cancer, esophageal cancer, skin cancer and non-small cell lung cancer (NSCLC). These findings suggest that MMP-10 may play an important role in the development and progression of malignant tumors.
Zhang G, et al. Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors[J]. BMC cancer, 2014, 14(1): 310.