Heat-shock proteins (HSPs) are molecular chaperones that regulate protein folding to ensure correct conformation and translocation and to avoid protein aggregation. Heat-shock proteins are increased in many solid tumours and haematological malignancies. Many oncogenic proteins responsible for the transformation of cells to cancerous forms are client proteins of HSP90, such as Prosurvival signalling molecules， Steroid hormone receptors，Steroid hormone receptors， Angiogeneic mediators， Apoptotic mediators Tumour suppressor genes，Cell cycle regulatory proteins and Mediators of tissue invasion and metastasis. Targeting HSP90 with chemical inhibitors would degrade these oncogenic proteins, and thus serve as useful anticancer agents.
Mahalingam D, Swords R, Carew JS, Nawrocki ST, Bhalla K, Giles FJ. Targeting HSP90 for cancer therapy. British Journal of Cancer. 2009;100(10):1523-1529.