CD96 has been reported to be expressed in T and NK cells, but not in B cells, granulocytes, monocytes, or RBCs. In nonhematopoietic tissue, CD96 is expressed in the convoluted tubular epithelium of the kidney, the mucosal epithelium of the small and large intestines, and the vascular endothelium. It was also reported that CD96 is expressed in ≈30% of human AML samples, regardless of disease subtype, by examining whole BM cells from AML patients with immunohistochemical-staining; its expression was rare in the FAB-M5 subtype.
Hosen N, Park CY, Tatsumi N, et al. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(26):11008-11013.