Drug Target for Cancer: B7-H3

Drug Targets for Cancer: B7-H3 and Cancer

The expression of B7-H3 in human tumor cells is positively correlated with the degree of disease malignancy, and B7-H3 participates in the process of tumor cell immune escape[3]. B7-H3 is highly expressed in many types of solid tumors, such as prostate cancer[4], pancreatic cancer[5], breast cancer[6], and gastric cancer[7]. Previous studies demonstrated a relationship between the expression of B7-H3 and poor prognosis in cancer patients[5,8,9]. The expression of B7-H3 is also closely related to colorectal cancer (CRC)[10]. Expression of B7-H3 not only has a negative relationship with prognosis in CRC[11] and the number of T cells in the tumor microenvironment[12] but also is positively correlated with invasion[13] and metastasis[14] in CRC.

Drug Targets for Cancer: B7-H3 related Products

Other vital drug targets for cancer like B7-H3:

Drug Targets for Cancer: B7-H3 Related Reference

Zhang T, Jiang B, Zou S-T, Liu F, Hua D. Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3. World Journal of Gastroenterology?: WJG. 2015;21(6):1804-1813.

Drug Targets for Cancer: B7-H3 Related Information