LAG3 Protein, Mouse, Recombinant (His Tag)
Cat: 53069-M08H
LAG3 Protein, Mouse, Recombinant (His Tag): Product Information
Purity
> 95 % as determined by SDS-PAGE.
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mouse Lag3 (NP_032505.1) (Met1-Leu442) was expressed with a polyhistidine tag at the C-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
Gly 24
Molecule Mass
The recombinant mouse Lag3 consists 431 amino acids and predicts a molecular mass of 46.8 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
LAG3 Protein, Mouse, Recombinant (His Tag): Images
LAG3 Protein, Mouse, Recombinant (His Tag): Synonyms
CD223 Protein, Mouse; LAG-3 Protein, Mouse; Ly66 Protein, Mouse
LAG3 Background Information
LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.
Full Name
lymphocyte-activation gene 3
Research Areas
References
- Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
- Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
- Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
- Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
- Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.
Human LAG3 Proteins
Rat LAG3 Proteins
Cynomolgus LAG3 Proteins
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