Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His Tag)

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Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His Tag): Product Information

Purity
> 90 % as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Activity
Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV).
The ED50 for this effect is 20-100 pg/mL.
Protein Construction
A DNA sequence encoding the mouse Ifna1 (NP_034632.2) (Cys24-Lys189) was expressed with a polyhistidine tag at the C-terminus.
Accession#
Expressed Host
Yeast
Species
Mouse
Predicted N Terminal
Cys 24
Molecule Mass
The recombinant mouse Ifna1 consists of 176 amino acids and predicts a molecular mass of 20.5 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His Tag): Images

Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is 20-100 pg/mL.

Interferon alpha 1/IFNA1 Protein, Mouse, Recombinant (His Tag): Synonyms

Ifa1 Protein, Mouse

Interferon alpha 1/IFNA1 Background Information

IFNA1, also known as IFN-alpha and IFNA, belongs to the alpha/beta interferon family. Interferons(IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites, or tumor cells. They belong to the large class of glycoproteins known as cytokines. IFNs stimulate the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs can activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes, and they also increase the ability of uninfected host cells to resist new infection by the virus. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon is produced by mitogen- or antigen-stimulated T lymphocytes. IFNA1 is produced by macrophages and has antiviral activities.
Full Name
interferon, alpha 1
References
  • Takayama I, et al. (2012) The nucleocapsid protein of measles virus blocks host interferon response. Virology. 424(1):45-55.
  • Vairo D, et al. (2011) Severe impairment of IFN-? and IFN-? responses in cells of a patient with a novel STAT1 splicing mutation. Blood. 118(7):1806-17.
  • Bhattacharya S, et al. (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFN? via accelerating the degradation of its receptor. Blood. 118(15):4179-87.
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