ST2/IL-1 RL1 Protein, Human, Recombinant (His Tag)

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ST2/IL-1 RL1 Protein, Human, Recombinant (His Tag): Product Information

Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to bind human IL33 (Cat: 10368-HNAE) in functional Elisa.
Protein Construction
A DNA sequence encoding the human IL1RL1 isoform 2 (NP_003847.2) (Met1-Phe328) was expressed fused with a polyhistidine tag at the C-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Lys 19
Molecule Mass
The recombinant human IL1RL1 consists of 321 amino acids and has a calculated molecular mass of 36.5 kDa. As a result of glycosylation, the apparent molecular mass of rhIL1RL1 is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ST2/IL-1 RL1 Protein, Human, Recombinant (His Tag): Images

ST2/IL-1 RL1 Protein, Human, Recombinant (His Tag): Synonyms

DER4 Protein, Human; FIT-1 Protein, Human; IL1RL1 Protein, Human; IL33R Protein, Human; IL‑1 R4 Protein, Human; ST2 Protein, Human; ST2L Protein, Human; ST2V Protein, Human; T1 Protein, Human

ST2/IL-1 RL1 Background Information

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage proinflammatory function. IL33 is a specific ligand of ST2L and induces the production of Th2 cytokines.
Full Name
interleukin 1 receptor-like 1
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
References
  • Savenije OE, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 127(3): 750-6.
  • Li H, et al. (2000) The cloning and nucleotide sequence of human ST2L cDNA. Genomics. 67(3): 284-90.
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