LAIR2 Protein, Human, Recombinant: Product Information
> 93 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
Measured by the ability of the immobilized protein to support the adhesion of HT-29 human colon adenocarcinoma cells
. When 5 x 10E4 cells/well are added to recombiannt human LAIR2 coated plates (50 μg/ml with 100 μl/well), >30% will adhere after 30 minutes at 37℃. Optimal concentration depends on cell type as well as the application or research objectives.
A DNA sequence encoding the human LAIR2 (NP_002279.2) (Met 1-Pro 152) was expressed and purified.
The secreted recombinant human LAIR2 comprises 131 amino acids with a predicted molecular mass of 14.1 kDa. As a result of glycosylation, the apparent molecular mass of rh LAIR2 is approximately 22 kDa in SDS-PAGE under reducing conditions.
Lyophilized from sterile 50mM Tris, 0.7M NaCl, pH 8.0 Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Leukocyte-associated immunoglobulin-like receptor 2 ( LAIR2 ), also known as CD36, is a 131 amino acid protein containing one Ig-like C2-type domain. It is expressed as a soluble receptor exhibiting high affinity for various collagen molecules to which it binds in a hydroxyproline-dependent manner. LAIR2 is a member of the immunoglobulin superfamily and was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. LAIR2 is thought to be secreted and may help modulate mucosal tolerance. As a natural competitor for LAIR1, soluble LAIR2 prevents binding of human LAIR1 to collagens and LAIR1 cross-linking, thereby regulating its inhibitory potential. Accordingly, LAIR2 is suggested to perform an immunoregulatory function.
leukocyte associated immunoglobulin like receptor 2
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