CD38 Protein, Human, Recombinant (ECD, His Tag)


CD38 Protein, Human, Recombinant (ECD, His Tag): Product Information

> 97 % as determined by SDS-PAGE
< 1.0 EU per μg of the protein as determined by the LAL method
1. Measured by its ability to convert the substrate nicotinamide guanine dinucleotide
(NGD+) to cyclic GDPribose.The specific activity is > 2,500 pmoles/min/μg.
2. Measured by its binding ability in a functional ELISA. Immobilized Human CD38 His (Cat:10818-H08H) at 2 μg/ml (100 μl/well) can bind Mouse Anti-CD38 Antibody (Cat:10818-MM03), the EC50 of Mouse Anti-CD38 Antibody is 30-120 ng/mL.
Protein Construction
A DNA sequence encoding the extracellular domain of human CD38 (NP_001766.2) (Val 43-Ile 300) with a C-terminal polyhistidine tag was expressed.
Expressed Host
HEK293 Cells
Predicted N Terminal
Val 43
Molecule Mass
The secreted recombinant human CD38 comprises 269 amino acids with a predicted molecular mass of 31.3 kDa. As a result of glycosylation, rhCD38 migrates as an approximately 43-45 kDa band in SDS-PAGE under reducing conditions.
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD38 Protein, Human, Recombinant (ECD, His Tag): Images

Measured by its binding ability in a functional ELISA. Immobilized Human CD38 His (Cat:10818-H08H) at 2 μg/ml (100 μl/well) can bind Mouse Anti-CD38 Antibody (Cat:10818-MM03), the EC50 of Mouse Anti-CD38 Antibody is 30-120 ng/mL.

CD38 Protein, Human, Recombinant (ECD, His Tag): Synonyms

ADPRC 1 Protein, Human; ADPRC1 Protein, Human; T10 Protein, Human

CD38 Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 38 (CD38), also known as ADP-ribosyl cyclase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It shares several characteristics with ADP-ribosyl cyclase 2 CD157. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. It also functions in cell adhesion, signal transduction and calcium signaling. CD38 has been used as a prognostic marker in leukemia. It can also be used to identify plasma cells.
Full Name
CD38 molecule
Research Areas
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Novel anti-CD38 humanized mAb SG003 possessed enhanced cytotoxicity in lymphoma than Daratumumab via antibody-dependent cell-mediated cytotoxicity
    Yu, T;Qiao, C;Lv, M;Tang, L;
    BMC Biotechnol.
    ELISA and SPR
  • Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells
    Gao, Z;Tong, C;Wang, Y;Chen, D;Wu, Z;Han, W;
    J Genet Genomics
  • A novel approach to remove interference of therapeutic monoclonal antibody with serum protein electrophoresis
    Liu, L;Shurin, MR;Wheeler, SE;
    Clin. Biochem.
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