EGFR Matched ELISA Antibody Pair Set,Human

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EGFR Matched ELISA Antibody Pair Set,Human General Information

Product name
EGFR Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human EGFR
Assay range
46.88-3000 pg/mL
Materials provided
1. Capture Antibody 1 mg/mL of rabbit anti-Human EGFR/HER1 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10001-RE11)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human EGFR/HER1 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.1 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10001-R021)
3. Standard Each vial contains 45 ng of recombinant Human EGFR/HER1. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3000 pg/mL is recommended.
Product overview
This EGFR Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human EGFR . It contains Human EGFR capture antibody, Human EGFR detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human EGFR protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

EGFR Matched ELISA Antibody Pair Set,Human Images

EGFR Matched ELISA Antibody Pair Set,Human: Synonyms

ERBB Matched ELISA Antibody Pair Set, Human; ERBB1 Matched ELISA Antibody Pair Set, Human; HER1 Matched ELISA Antibody Pair Set, Human; mENA Matched ELISA Antibody Pair Set, Human; NISBD2 Matched ELISA Antibody Pair Set, Human; PIG61 Matched ELISA Antibody Pair Set, Human

EGFR Background Information

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Full Name
epidermal growth factor receptor
Related Pathways
  • EGFR Signaling Pathway
    EGFR Signaling Pathway
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
References
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
  • Extracellular domain shedding influences specific tumor uptake and organ distribution of the EGFR PET tracer 89Zr-imgatuzumab
    Author
    Pool, M;Kol, A;Lub-de Hooge, MN;Gerdes, CA;de Jong, S;de Vries, EG;Terwisscha van Scheltinga, AG;
    Year
    2016
    Journal
    Oncotarget
    Application
    ELISA
  • Integrative gene ontology and network analysis of coronary artery disease associated genes suggests potential role of ErbB pathway gene EGFR
    Author
    Ghatge, M;Nair, J;Sharma, A;Vangala, RK;
    Year
    2018
    Journal
    Mol Med Rep
    Application
    ELISA
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