MYT1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All MYT1 reagents are produced in house and quality controlled, including 2 MYT1 Antibody, 1 MYT1 Gene. All MYT1 reagents are ready to use.

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MYT1 Background

MYT1, encoding the myelin transcription factor 1, was reported as the first gene involved in OAVS, within the retinoic acid (RA) pathway. MYT1 overexpression downregulated all RA receptors genes (RARA, RARB, RARG), involved in RA-mediated transcription, whereas no effect was observed on CYP26A1 expression, the major enzyme involved in RA degradation. Oculo-auriculo-vertebral spectrum (OAVS) is a developmental disorder characterized by hemifacial microsomia associated with ear, eyes and vertebrae malformations showing highly variable expressivity.MYT1 is the first gene implicated in OAVS, within the RA signalling pathway.The MYT1 immunoreactivity was frequently nuclear, appearing as dotted or punctate, but in some cases it was localized to the cytoplasm.