Anti-IL17RB Antibody

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Anti-IL17RB Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-IL17RB Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL17RB
Immunogen
Recombinant Mouse IL17BR / IL17RB / IL-17 Receptor B protein (Catalog#51109-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IL17BR / IL17RB / IL-17 Receptor B (Catalog#51109-M08H; Q9JIP3-1; Met1-Gly286). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL17RB Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL17RB Antibody: Alternative Names

Anti-Evi27 Antibody; Anti-IL-17ER Antibody; Anti-IL-17Rh1 Antibody; Anti-Il17br Antibody; Anti-IL17RH1 Antibody

IL17RB Background Information

IL17RB is the receptor for IL17E, the only member of IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and short survival of the breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in the cell growth, proliferation and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics.
Full Name
interleukin 17 receptor B
References
  • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
  • Stock P, et al.. (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 182(8): 5116-22.
  • Wang H, et al.. (2010) Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy. 40(8): 1194-202.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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