CXCL11 (Protein | Antibody | cDNA Clone | ELISA Kit)

All CXCL11 reagents are produced in house and quality controlled, including 5 CXCL11 Antibody, 1 CXCL11 ELISA, 26 CXCL11 Gene, 2 CXCL11 Protein, 2 CXCL11 qPCR. All CXCL11 reagents are ready to use.

CXCL11 Protein (2)

    CXCL11 Antibody (5)

      CXCL11 ELISA Kit & Match Antibody ELISA Pair Set (1)

      CXCL11 cDNA Clone (26)

      NM_005409.3
      NM_019494.1

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      CXCL11 Background

      I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL1. I-TAC is chemotactic for activated T cells. The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

      CXCL11 References

      • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
      • Rani MR, et al. (2002) Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. J Biol Chem. 277(41): 38456-61.
      • Salmaggi A, et al. (2003) Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J Interferon Cytokine Res. 22(6):631-40.

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