S100P Protein, Human, Recombinant, Biotinylated

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S100P Protein, Human, Recombinant, Biotinylated: Product Information

Purity
> 90% as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the mature form of human S100P (P25815) (Met 1-Lys 95 ) was expressed and purified.
Accession#
Expressed Host
E. coli
Species
Human
Predicted N Terminal
Met 1
Molecule Mass
The recombinant human S100P consisting of 95 amino acids and has a calculated molecular mass of 10.4 kDa.
Formulation
Lyophilized from sterile Sterile PBS
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

S100P Protein, Human, Recombinant, Biotinylated: Images

S100P Protein, Human, Recombinant, Biotinylated: Alternative Names

MIG9 Protein, Human

S100P Background Information

Protein S1-P, also known as Protein S1-E, S1 calcium-binding protein P, S1P and S1E, is a nucleus and cytoplasm protein which belongs to theS-1 family. S1P / S1E contains twoEF-hand domains. S1P protein regulates calcium signal transduction and mediates cytoskeletal interaction, protein phosphorylation and transcriptional control. S1P / S1E overexpression can upregulate androgen receptor expression and thereby promote prostate cancer progression by increasing cell growth. S1P / S1E may directly confer resistance to chemotherapy. S1P / S1E induction may be considered an important step in the initial stage of lung adenocarcinomas, whereas its downregulation in advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role. S1P / S1E plays a major role in the aggressiveness of pancreatic cancer that is likely mediated by its ability to activate RAGE. Interference with S1P / S1E may provide a novel approach for treatment of pancreatic cancer. S1P / S1E could be considered a potential drug target or a chemosensitization target, and could also serve as a biomarker for aggressive, hormone-refractory and metastatic prostate cancer.
Full Name
S100 calcium binding protein P
References
  • Arumugam,T. et al., 2005, Clin Cancer Res. 11 (15): 5356-64.
  • Basu,G.D. et al., 2008, Int J Cancer. 123 (2): 330-9.
  • Rehbein,G. et al., 2008,Int J Mol Med. 22 (1): 69-77.
  • Heil,A. et al., 2011, J Biol Chem. 286 (9): 7227-38.
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