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FZD3/frizzled 3  Protein, Antibody, ELISA Kit, cDNA Clone

FZD3/frizzled 3 Related Area

FZD3/frizzled 3 Related Pathways

FZD3/frizzled 3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

FZD3/frizzled 3 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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FZD3/frizzled 3 Summary & Protein Information

FZD3/frizzled 3 Background

Subunit structure: Interacts with VANGL2. {ECO:0000250}.
Domain: Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. {ECO:0000250}.; The FZ domain is involved in binding with Wnt ligands. {ECO:0000250}.
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell surface {ECO:0000250|UniProtKB:Q61086}. Apical cell membrane {ECO:0000250|UniProtKB:Q61086}; Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity). {ECO:0000250|UniProtKB:Q61086}.
Tissue specificity: Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Post-translational: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
Sequence similarity: Belongs to the G-protein coupled receptor Fz/Smo family. {ECO:0000305}.; Contains 1 FZ (frizzled) domain. {ECO:0000255|PROSITE-ProRule:PRU00090}.
General information above from UniProt

FZD3/frizzled 3 Alternative Name

Fz-3, [homo-sapiens]
Fz3,AU020229,D930050A07Rik, [mus-musculus]

FZD3/frizzled 3 Related Studies

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