Anti-EPCR Antibody (FITC)

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Anti-EPCR Antibody (FITC) (Rabbit Monoclonal antibody) General Information

Product name
Anti-EPCR Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse EPCR
Immunogen
Recombinant Mouse Epcr/PROCR Protein (Catalog#50874-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Epcr/PROCR (rM Epcr/PROCR; Catalog#50874-M08H; Q64695; Met1-Ser214) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Rabbit IgG Clone #016
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-EPCR Antibody (FITC) (Rabbit Monoclonal antibody) Images

Flow cytometric analysis of Mouse PROCR(CD201) expression on bEnd.3 cells. Cells were stained with FITC-conjugated anti-Mouse PROCR(CD201). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-EPCR Antibody (FITC): Alternative Names

Anti-AI325044 Antibody; Anti-Ccca Antibody; Anti-Ccd41 Antibody; Anti-Epcr Antibody

EPCR Background Information

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.
Full Name
protein C receptor, endothelial
References
  • Nicolaes GA, et al. (2003). Congenital and acquired activated protein C resistance. Semin Vasc Med. 3 (1): 33-46.
  • Esmon CT. ( 2003). The protein C pathway. Chest 124 (3): 26-32.
  • Mosnier LO, et al. (2007)The cytoprotective protein C pathway. Blood. 109: 3161-72.

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