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IL36B / IL1F8 Antibody, Rabbit PAb

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Expression host: E. coli  
  • Slide 1
10579-HNAE-50
10579-HNAE-20
50 µg 
20 µg 
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Expression host: E. coli  
  • Slide 1
  • Slide 1
10579-H07E1-20
10579-H07E1-10
20 µg 
10 µg 
Add to Cart
Expression host: E. coli  
  • Slide 1
51071-MNAE-50
51071-MNAE-20
50 µg 
20 µg 
Add to Cart

IL36B/IL1F8 AntibodyRelated Products

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IL36B/IL1F8 antibody Background

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

Human IL36B/IL1F8 antibody References
  • Magne D, et al. (2006) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Research & Therapy. 8: R80.
  • Smith DE, et al. (2000) The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. The Journal of Biological Chemistry. 275: 1169-75.
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