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TRP1 / TYRP1 Antibody, Rabbit PAb

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Expression host: Baculovirus-Insect Cells  
  • Slide 1
13224-H08B-20
13224-H08B-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
13224-H08H-50
13224-H08H-20
50 µg 
20 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
51289-M08B-50
51289-M08B-20
50 µg 
20 µg 
Add to Cart

TRP1 / TYRP1 AntibodyRelated Products

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TRP1 / TYRP1 antibody Background

Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 (TYRP1) is regulated by the microphthalmia-associated transcription factor (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of tyrosinase proliferation and melanocyte cell death.

Human TRP1 / TYRP1 antibody References
  • Sarangarajan R, et al. (2001) Tyrp1 and oculocutaneous albinism type 3. Pigment Cell Res. 14(6): 437-44.
  • Box NF, et al. (1998) Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. Genome. 9 (1): 50-3.
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