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DOPA Decarboxylase / DDC Antibody, Rabbit PAb

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Description: Active  
Expression host: Baculovirus-Insect Cells  
  • Slide 1
10560-H08B-50
10560-H08B-20
10560-H08B-10
50 µg 
20 µg 
10 µg 
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Expression host: Baculovirus-Insect Cells  
  • Slide 1
50799-M08B-20
50799-M08B-100
20 µg 
100 µg 
Add to Cart

DOPA Decarboxylase/DDC ELISA Pair Set

Detection Limit: 62.5 pg/ml
SEK10560-5
SEK10560-15
5 Plates 
15 Plates 
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DOPA Decarboxylase/DDC antibody Background

Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson's disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.

Mouse DOPA Decarboxylase/DDC antibody References
  • Ichinose, H. et al.,1989,Biochem. Biophys. Res. Commun. 164: 1024-1030.
  • Lisa, J. S. et al., 1992, Genomics 13: 469-471.
  • Moore, P. S. et al.,1996, Biochem. J. 315:249-256.
  • Bertoldi, M. et al., 2003, Biochim. Biophys. Acta. 1647:42-47.
  • Vassilacopoulou, D. et al., 2004, Neurochem. Res. 29: 1817-1823.
  • Ma, J.Z., et al., 2005, Hum. Mol. Genet. 14: 1691-1698.
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